Cancer and Cytokines link even with depression?

“Inflammation is our immune system’s natural response to injuries, infections, or foreign compounds. When triggered, the body pumps various cells and proteins to the site through the blood stream, including cytokines, a class of proteins that facilitate intercellular communication.  It also happens that people suffering from depression are loaded with cytokines.” 

Mg for Magnesium deficiency might be accompanied by the activation of cells such as macrophages, neutrophils and endothelial cells (Mak et al, 1997; Malpuech-Brugère et al, 2000).

Known as HMGB1 (for “High Mobility Group Box-1”), this intriguing protein molecule triggers the release of the cytokines—a collection of chemical signals—that generateinflammation in your body.
Chronic inflammation is another matter entirely—it has been linked with many age-related, lifespan-shortening disorders, including heart disease, cancer, chronic obstructive pulmonary disease (COPD), diabetes, and others.

This released HMGB1 binds to receptor molecules on immune system cells, acting as a “danger signal” that triggers them to release cytokines.1,7 Cytokines, in turn, are chemical signaling molecules that call in still more white blood cells, which release still more cytokines, in a deadly frenzy of activity.

Elevated HMGB1 levels have now been found to be associated with many acute and chronic inflammation-related disorders, including:

  

• Asthma and chronic obstructive pulmonary disease (COPD)
• Atherosclerosis, lipid disturbances, and their consequences, coronary artery disease, heart attacks, strokes, and congestive heart failure
• Autoimmune disorders, including lupus, multiple sclerosis, rheumatoid arthritis, type I diabetes, and others
• Cancer
• Diabetes
• Inflammatory bowel diseases (Crohn’s disease and ulcerative colitis)
• Neurodegenerative disorders
• Obesity
• Surgical procedures, even those without obvious complications
• Trauma, including hemorrhagic shock, traumatic brain injury, acute lung injury and bone fractures
• Viral and other infections